Music

I love many kinds of music and had went through various change in musical preference. From indie to mainstream. From classical music to jazz. Music is very important for me.

Books

A little bit different from other girls, rather than spend my money to buy clothes, shoes, or cosmetics, I usually choose to buy books instead.

Pharmacy

Pharmacists are healthcare professionals who practice in pharmacy, the field of health sciences focusing on safe and effective medication use. For me the science of pharmacy is fascinating and interesting.

Movie

I'm a movie enthusiast. Particularly for Fantasy, Adventure, Animation and Science-Fiction Movie. It's a nice way to escape the reality for a while.

Anime and Manga

I love to read manga and watch anime ^^

Sunday, February 23, 2014

The Lego Movie (review)

I've watched this movie 2 weeks ago but feel reluctant to write my thought about it. Contrary to the critics and most user who praise and think highly of this movie, I have a mixed feeling about it. If you curious why, continue to read this review below.


First of all, the animation of this movie is great. The cinematography is great and the world depicted in this movie is beautiful. The music score and soundtrack is so-so. Not special but sufficiently interesting. This movie is clearly an advertisement for Lego but I applaud the use of many interesting cameos in it. The addition and parody of Batman, Superman, Han Solo, etc made me laugh in cinema and some of it hilarious. I will certainly love this movie if not for the story that I think is cliche as hell. Something cliche is forgivable for me if I feel some connection to its story.  I can relate myself with Toy Story and Wreck-it Ralph but it's not the same for this movie even though I'd played Lego when I was a child. I don't know. Maybe it's because I have an overly high expectation about this movie when I saw it got a score of 8,6 in IMDb.

Overall, I still think The Lego Movie is a good movie. But in my opinion it's not a great one. I think the humor in this movie is a liitle nerdy. Anyone who don't know about Star Wars or superhero universe might not understand some of it's joke. But I'm sure it still can entertain many people. That's my opinion about this movie. What about yours?

Sunday, February 16, 2014

Interaksi Obat antara Clarithromycin dan Penghambat Kanal Kalsium (Calcium-Channel Blocker)

Berdasarkan penelitian baru, pemberian antibiotik Clarithromycin pada pasien yang sebelumnya telah menggunakan obat Penghambat Kanal Kalsium (Calcium-Channel Blocker) sebagai terapi antihipertensi diasosiasikan dengan peningkatan risiko rawat inap akibat gagal ginjal akut, hipotensi dan kematian. Latar belakang dilakukannya penelitian ini adalah karena obat-obat tersebut masih sering diresepkan secara bersamaan meskipun FDA mengharuskan pencantuman peringatan,"serious adverse reactions have been reported in patients taking clarithromycin concomitantly with CYP3A4 substrates, which includes hypotension with calcium-channel blockers metabolized by CYP3A4 (such as verapamil, amlodipine, diltiazem)". Tampaknya masih ada keraguan dokter dan apoteker tentang bahaya interaksi obat tersebut sehingga diperlukan studi baru untuk melihat seberapa besar risiko yang ditimbulkan karena peresepan obat-obat tersebut secara bersamaan.


Picture source: https://aronberglaw.com
Clarithromycin adalah antibiotik makrolida yang sering digunakan untuk mengobati infeksi saluran pernapasan, sementara Penghambat Kanal Kalsium seperti amlodipine, felodipine, nifedipine, diltiazem, dan verapamil adalah obat antihipertensi.  Penghambat Kanal Kalsium dimetabolisme oleh enzim cytochrome P450 3A4 (CYP3A4). Kadar Penghambat Kanal Kalsium dalam darah dapat meningkat ke level yang berbahaya jika enzim tersebut dihambat. Clarithromycin merupakan inhibitor kuat CYP3A4 sehingga peresepan kedua obat ini secara bersamaan dapat meningkatkan efek tidak diinginkan dari Penghambat Kanal Kalsium yaitu hipotensi. Kondisi hipotensi ini dapat menyebabkan gagal ginjal akut dan kematian.

Subjek penelitian ini adalah lansia berusia diatas 76 tahun. Pada populasi ini, penggunaan bersama Penghambat Kanal Kalsium dengan clarithromycin diasosiasikan dengan peningkatan risiko rawat inap akibat gagal ginjal akut, jika dibandingkan dengan penggunaan bersama azithromycin (bukan inhibitor CYP3A4). Sejawat dokter dan apoteker agar menghindari kombinasi Clarithromycin  Penghambat Kanal Kalsium seperti amlodipine, felodipine, nifedipine, diltiazem, dan verapamil.